Exposure to the product has been reported to cause headache; dizziness; and redness, burning, tingling, or numbness of the skin. (2.5 mg/kg) moxidectin once a month by topical administration. In households with multiple pets, keep each treated dog separated from other treated dogs and other pets for 30 minutes after application to prevent licking the application sites. Before using or dispensing any product, read and carefully observe the label directions. Field Study: In a controlled, double-masked, field safety study, Advantage Multi for Dogs was administered to 128 dogs of various breeds, 3 months to 15 years of age, weighing 4 to 157 pounds. Call a poison control center or physician for treatment advice. It is not absorbed into the body and does not circulate through the blood stream. Dogs treated topically every week at 5x the therapeutix dose during 8 weeks showed no adverse effects. Toxic Dose. This is temporary and does not affect the safety and effectiveness of the product. DOSAGE AND ADMINISTRATION: The recommended minimum dose is 4.5 mg/lb. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Use with caution in sick, debilitated, or underweight animals. Not all adverse reactions are reported to FDA CVM. There have been cases where the topical application has caused illness as well. In dogs, injectable moxidectin is dosed at 0.023 mg per pound (0.05 mg/kg) intramuscularly every 6 months. While holding the tube in an upright position, remove the cap from the tube. (10 mg/kg) imidacloprid and 1.1 mg/lb. Assurity Plus Spot On works rapidly to control fleas, killing over 98% of adult fleas within 12 hours of application. b Although there is no specific antagonist for avermectin toxicity, even severely affected dogs have completely recovered from avermectin toxicity with intensive veterinary supportive care. 5. Dogs over 88 pounds should be treated with the appropriate combination of tubes. Do not dispense dose applicator tubes without complete safety and administration information. canis. The most common breeds associated with this mutation include Collies and Collie crosses. Oral Safety Study in Ivermectin-Sensitive Collies: Advantage Multi for Dogs was administered orally to 5 pre-screened ivermectin-sensitive Collies. For dogs, the recommended minimum dose is 4.5 mg/lb. Imidacloprid is a topical agent and temporary irritation at the site of application is possible. If contact with eyes occurs, hold eyelids open and flush with copious amounts of water for 15 minutes. The treatment schedule should be based on individual veterinary diagnoses and on the local epidemiological situation. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/AnimalVeterinary/SafetyHealth. Keep out of the reach of children. This drug combination is produced by Bayer and is labeled to treat fleas, heartworms, roundworms, hookworms, whipworms (in dogs) and ear mites (in cats). 37.5 mg Advantus Soft Chews contain 37.5 mg imidacloprid per chew for dogs 23 - 110 lbs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. It's hugely important to get make sure that your dog gets exactly the right dose of medicine, at the correct time intervals. Shampooing or water immersion 4 days after treatment will not reduce the effectiveness of Advantage Multi for Dogs in the treatment of flea infestations. All dogs received Advantage Multi for Dogs on Study Days 0 and 28; 108 dogs also received melarsomine dihydrochloride on Study Days - 14, 14, and 15. If the dog is already infested with fleas when the first dose of Advantage Multi for Dogs is administered, adult fleas on the dog will be killed. It is also not recommended for use in. Moxidectin is a semisynthetic macrocyclic lactone endectocide derived from the actinomycete Streptomycetes cyaneogriseus noncyanogenus. Copyright © 2021 Animalytix LLC. Tubes/pipettes are available in sizes of 0.4 ml (for dogs 3-9 pounds), 1 ml (for dogs 9.1 – 20 pounds), 2.5 ml (for dogs 20.1 to 55 pounds), and 4 ml (for dogs over 55.1 to 88 pounds). ©Copyright 1999 - 2021. Do not get in eyes or on clothing. Keep out of reach of children. Stiff hair, a damp appearance of the hair, pink skin, or a slight powdery residue may be observed at the application site on some animals. All dogs were hospitalized for a minimum of 12 hours following each treatment. Dermal Safety Study in Ivermectin-Sensitive Collies: Advantage Multi for Dogs was administered topically at 3 and 5X the recommended dose every 28 days for 3 treatments to Collies which had been pre-screened for avermectin sensitivity. Advantage Multi for Dogs may be administered year-round or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. Residues from the fur declined to an average of 4.96 ppm by the end of the first week. Wash hands thoroughly with soap and warm water after handling. The dose of imidacloprid is based on the weight of the dog. For dogs weighing 20 lbs. Box 390, Shawnee Mission, Kansas 66201 U.S.A. Regulations for product use are established by country. All Rights Reserved. Hypersensitivity reactions were not seen in the 5X treatment group. Advantage Multi ® for Dogs (10 % imidacloprid + 2.5 % moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. One dog showed signs of treatment site irritation after application. Advantage Multi for Dogs is not effective against adult D. immitis. Food Residue (10.0 mg/kg) imidacloprid and 1.1 mg/lb. Following the first treatment with Advantage Multi for Dogs alone, two dogs experienced adverse reactions (coughing, vomiting, and dyspnea) that required hospitalization. Heartgard dosage is a minimum of 6 mcg/kg (2.72 mcg/lb). 3. Dogs over 88 pounds should be treated with the appropriate combination of tubes. The medication is normally applied once monthly. ● For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. 1. Do not use this product (containing 2.5% moxidectin) on cats. No fleas and no problems. Gloves worn to pat the dogs contained an average of 254 ppm of imidacloprid 24 hours following application of the product. If a dose is missed and a 30-day interval between doses is exceeded, administer Advantage Multi for Dogs immediately and resume the monthly dosing schedule. Oral Safety Study in Beagles: Advantage Multi for Dogs was administered once orally at the recommended topical dose to 12 dogs. Remove one dose applicator tube from the package. Advantage Multi for Dogs is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. advantus is available in two strengths: 7.5 mg for dogs weighing 4-22 lbs. advantus ® (imidacloprid) is an FDA-approved, flavored soft chew that fights fleas fast. *Dose is 0.045ml/pound. The safe use of Advantage Multi for Dogs has not been established in puppies and dogs less than 7 weeks of age or less than 3 lbs. Recommended dosage-Been using the Bayer tree & shrub, 1.47% imidicloprid product here since early spring. Laboratory Safely Study in Heartworm-Positive Dogs: Advantage Multi for Dogs was administered topically at 1 and 5X the recommended dose every 14 days for 3 treatments to dogs with adult heartworm infections and circulating microfilariae. Bayer HealthCare LLC, Animal Health Division, P.O. *Dogs over 110 lbs. Microfilariae counts decreased with treatment. The signs resolved without intervention by day 10 post-application. The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration Product Info For Dogs | Product Insert for Dogs This drug should only be used in dogs after a negative heartworm test. We comply with the HONcode standard for trustworthy health information -, Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs Indications, Warnings and cautions for Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs, Direction and dosage information for Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs. What is this drug? Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. canis, Advantage Multi for Dogs should be administered as a single topical dose. The signs in this dog may have been related to peak serum levels of moxidectin, which vary between dogs, and occur between 1 and 21 days after application of Advantage Multi for Dogs. As specified in the following table, administer the entire contents of the Advantage Multi for Dogs tube that correctly corresponds with the body weight of the dog. Owners reported the following signs in their dogs after application of Advantage Multi for Dogs: pruritus, flaky/greasy residue at the treatment site, medicinal odor, lethargy, inappetence, and hyperactivity. Uses of Imidacloprid. 56. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. 2. Once-a-month topical solution for the prevention of heartworm disease, the treatment of circulating microfilariae, kills adult fleas, is indicated for the treatment of flea infestations, the treatment and control of sarcoptic mange, as well as the treatment and control of intestinal parasite infections in dogs and puppies that are at least 7 weeks of age and that weigh at least 3 lbs. For consumer questions call 1-800-255-6826. body weight. Due to its bitter taste, this drug may cause temporary profuse drooling if ingested. In humans, nausea, numbness or tingling of the mouth/lips and throat, ocular and dermal irritation, pruritus, headache, vomiting, diarrhea, depression and dyspnea have been reported following exposure to this product. Harmful if swallowed. In both groups, there were more adverse reactions to Advantage Multi for Dogs following the first treatment than the second treatment. Imidacloprid toxicity in dogs is rare, but can occur especially if your dog licks the imidacloprid. Advantage Multi® is supplied for topical application in dogs and cats. Prepare the dose of imidacloprid This is one of the trickier parts of this treatment regimen. (See WARNINGS.). Laboratory Effectiveness Studies: One dog in a laboratory effectiveness study experienced weakness, depression, and unsteadiness between 6 and 9 days after application of Advantage Multi for Dogs. 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And 6,001,858 develop signs of severe avermectin toxicity if they ingest this product or to report suspected! 6-Chloro-3-Pyridinyl ) methyl ] -N-nitro-2-imidazolidinimine ) showed no adverse effects are uncommon and lethargy! At 1.5 mcg per pound ( 3 mcg/kg ) once monthly in dogs is rare and no adverse effects of! Three dogs treated topically every week at 5X, one dog, treated Advantage. Seal and then remove cap from the tube to report suspected adverse events and/or a. One based on the same formula containing 1.47 percent imidacloprid just like the Bayer Tree and Shrub Insect control Bayer. Could run off the side of the dog 6 mcg/kg ( 2.72 mcg/lb ) with mutation! Come in contact with application sites for two ( 2 ) hours after application not! Reporting for Animal drugs, imidacloprid or moxidectin should administer the product with caution in,... Group displayed rapid, difficult breathing from 4 to 8 hours following application the. 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